Product Name :
2-Ethylhexyl 4-Methoxycinnamate (CAS 5466-77-3)
Synonym :
Octinoxate; 4-Methoxycinnamic acid 2-ethylhexyl ester; Octyl methoxycinnamate
Application :
2-Ethylhexyl 4-Methoxycinnamate is is an UV induced cyclobutane pyrimidine dimer (CDP) formation inhibitior
CAS:
5466-77-3
Purity:
Molecular Weight:
290.40
Formula :
C18H26O3
Physical state:
Liquid
solubility :
Soluble in ethanol (75% – 80 vol%), diethylphthalate, paraffin oli 65 cp, and isopropylmyristat. Insoluble in water.
Shipping Condition :
Store at room temperature
Melting point:
<-25° C
SMILES:
CCCCC(CC)COC(=O)/C=C/C1=CC=C(C=C1)OC
References:
:Transdermal penetration of UV filters. | Klinubol, P., et al. 2008. Skin Pharmacol Physiol. 21: 23-9. PMID: 17912021Measurements of octanol-air partition coefficients, vapor pressures and vaporization enthalpies of the (E) and (Z) isomers of the 2-ethylhexyl 4-methoxycinnamate as parameters of environmental impact assessment. | Pegoraro, CN., et al. 2015. Chemosphere. 138: 546-52. PMID: 26210018Formation of chlorinated breakdown products during degradation of sunscreen agent, 2-ethylhexyl-4-methoxycinnamate in the presence of sodium hypochlorite. | Gackowska, A., et al. 2016. Environ Sci Pollut Res Int. 23: 1886-97. PMID: 26408113The effect of UV-filters on the viability of neuroblastoma (SH-SY5Y) cell line. | Broniowska, Ż., et al. 2016. Neurotoxicology. 54: 44-52. PMID: 26965011Estimation of physicochemical properties of 2-ethylhexyl-4-methoxycinnamate (EHMC) degradation products and their toxicological evaluation. | Gackowska, A., et al. 2018. Environ Sci Pollut Res Int. 25: 16037-16049. PMID: 29594898Two-generation exposure to 2-ethylhexyl 4-methoxycinnamate (EHMC) in Japanese medaka (Oryzias latipes) and its reproduction and endocrine related effects.Piperazine-2,6-dione Data Sheet | Lee, I.Formula of 1048962-49-7 , et al.PMID:33600274 2019. Chemosphere. 228: 478-484. PMID: 31051350Analysis of photokinetics of 2′-ethylhexyl-4-methoxycinnamate in sunscreens. | Herzog, B., et al. 2019. Photochem Photobiol Sci. 18: 1773-1781. PMID: 31112187Alginate microparticles as carriers for the UV filter 2-ethylhexyl 4-methoxycinnamate: Influence on photostability. | Duarte, J., et al. 2019. Int J Cosmet Sci. 41: 585-593. PMID: 31509264Effects of Sulfamethoxazole and 2-Ethylhexyl-4-Methoxycinnamate on the Dissimilatory Nitrate Reduction Processes and N2O Release in Sediments in the Yarlung Zangbo River. | Xu, H., et al. 2020. Int J Environ Res Public Health. 17: PMID: 32168922Effects of 2-ethylhexyl-4-methoxycinnamate (EHMC) on thyroid hormones and genes associated with thyroid, neurotoxic, and nephrotoxic responses in adult and larval zebrafish (Danio rerio). | Chu, S., et al. 2021. Chemosphere. 263: 128176. PMID: 33297144Biodegradation of 2-ethylhexyl-4-methoxycinnamate in river sediments and its impact on microbial communities. | Zhang, P., et al. 2021. J Environ Sci (China). 104: 307-316. PMID: 33985734Relationship between the ability of sunscreens containing 2-ethylhexyl-4′-methoxycinnamate to protect against UVR-induced inflammation, depletion of epidermal Langerhans (Ia+) cells and suppression of alloactivating capacity of murine skin in vivo. | Walker, SL., et al. 1994. J Photochem Photobiol B. 22: 29-36. PMID: 8151453Sunscreen allergy in Singapore. | Ang, P., et al. 1998. Am J Contact Dermat. 9: 42-4. PMID: 9471986