Product Name :
THOC5 Rabbit Polyclonal Antibody
Predicted band size :
Observed band size :
Synonyms:
C22orf19 antibody Chromosome 22 open reading frame 19 antibody Fmip antibody Fms interacting protein antibody fSAP79 antibody Functional spliceosome-associated protein 79 antibody hTREX90 antibody KIAA0983 antibody LOC400922 antibody NF2/meningioma region protein pK1.3 antibody 展开
Function :
Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA.2-Bromo-5,8-dioxaspiro[3.4]octane Price TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5′ end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway.DOTA-tri(t-butyl ester) web The TREX complex is essential for the export of Kaposi’s sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production.PMID:33454950 THOC5 in conjunction with ALYREF/THOC4 functions in NXF1-NXT1 mediated nuclear export of HSP70 mRNA; both proteins enhance the RNA binding activity of NXF1 and are required for NXF1 localization to the nuclear rim. Involved in transcription elongation and genome stability. Involved in alternative polyadenylation site choice by recruiting CPSF6 to 5′ region of target genes; probably mediates association of the TREX and CFIm complexes.
Antibody Type:
Rabbit Polyclonal Antibody
Immunogen :
Recombinant protein within human THOC5 aa 1-200.
Species reactivity:
Human, Mouse, Rat
Verify application:
WB, IHC-P
Coupling :
unconjugated
Clone number:
RRID:
AB_3071227
Form :
Liquid
Concentration :
1ug/ul
Storage instructions:
Store at +4℃ after thawing. Aliquot store at -20℃. Avoid repeated freeze / thaw cycles.
Storage buffer solution:
1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Subtype:
IgG
Purification method :
Immunogen affinity purified.
ELTSA :
Molecular weight :
79 kDa
Positive control :
NIH/3T3 cell lysate, PC-12 cell lysate, Hela cell lysate, HepG2 cell lysate, human ovarian tumor tissue, mouse brain tissue.