Product Name :
TCF7L2 Recombinant Rabbit Monoclonal Antibody [SC06-90]
Predicted band size :
68 kDa
Observed band size :
68 kDa
Synonyms:
HMG box transcription factor 4 antibody hTCF 4 antibody hTCF-4 antibody T cell factor 4 antibody T cell specific HMG box antibody T cell specific transcription factor 4 antibody T-cell factor 4 antibody T-cell-specific transcription factor 4 antibody TCF 4 antibody TCF-4 antibody 展开
Function :
T cell factors (TCFs) comprise a family of DNA-binding transcriptional activators that are essential for lymphoid cell development. These transcription factors are activated by the Wnt-1 and Wingless pathways and are characterized by the presence of a conserved protein motif, the high mobility group (HMG) 1 box, which mediates DNA binding. TCF-4 mainly localizes in the cytoplasm and is transported into the nucleus directly bound to β-catenin in a cooperative manner. This TCF-4/β-catenin complex induces expression of Wnt target genes, including multiple cancer-associated genes.6-(Trifluoromethyl)piperidin-2-one Formula c-Jun also interacts with TCF-4 and β-catenin, and the phosphorylation-dependent interaction between c-Jun and TCF4 regulates intestinal tumorigenesis by integrating JNK and APC/β-catenin. TCF-4 is also implicated in bipolar affective disorder.
Antibody Type:
Recombinant Rabbit monoclonal Antibody
Immunogen :
Synthetic peptide within Human TCF7L2 aa 1-49 / 619.501015-16-3 Chemscene
Species reactivity:
Human, Mouse, Rat
Verify application:
WB, IF-Cell, IF-Tissue, IHC-P, IP, FC
Coupling :
unconjugated
Clone number:
SC06-90
RRID:
AB_3069958
Form :
Liquid
Concentration :
1ug/ul
Storage instructions:
Store at +4℃ after thawing.PMID:33622083 Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
Storage buffer solution:
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Subtype:
IgG
Purification method :
Protein A affinity purified.
ELTSA :
Molecular weight :
Predicted band size: 68 kDa
Positive control :
HepG2 cell lysate, HeLa cell lysate, HeLa, mouse brain tissue, mouse hippocampus tissue, mouse testis tissue, rat testis tissue, human breast carcinoma tissue, human kidney tissue, Jurkat.